alpha retinal ganglion cell (Mmus) alpha retinal ganglion cell OFF-sustained (Mmus) alpha retinal ganglion cell OFF-s C42 GitHub Copilot G5 The G-type nomenclature used here refers specifically to the functional classification of mouse retinal ganglion cells introduced by Baden and colleagues, and is distinct from earlier G-based schemes used for rabbit or other species. Readers should be aware that the same letter–number labels (e.g., "G1", "G2") have been applied in different historical contexts to different animals and criteria (functional vs. morphological), so cross-species or cross-era comparisons of "G" names should not be assumed equivalent without explicit mapping in the primary literature. A mouse retinal ganglion cell type defined by a large soma and a wide, monostratified dendritic arbor that stratifies just distal to the outer ChAT band of the inner plexiform layer (Krieger et al., 2017). It corresponds to the G5 physiological type (Baden et al., 2016; Goetz et al., 2022) and the C42 transcriptomic cluster (Tran et al., 2019), and is considered the evolutionary ortholog of the primate OFF midget RGC (Hahn et al., 2023). The cell projects a thick, fast-conducting axon to the dorsal lateral geniculate nucleus and superior colliculus. It shows a sustained increase in firing to light decrements with a slow decay time constant of roughly 250 ms and a large receptive field center with weak surround antagonism (Krieger et al., 2017). Its molecular profile includes expression of Spp1 and Neurofilament (Smi32) together with Brn3a (Pou4f1) and Brn3b (Pou4f2), absence of Brn3c (Pou4f3) and Calbindin (Calb1), and strong enrichment of Fes (Krieger et al., 2017; Tran et al., 2019). OFF retinal ganglion cell Mus musculus