alpha retinal ganglion cell (Mmus) alpha retinal ganglion cell OFF-transient (Mmus) 2025-12-05T11:29:19Z The G-type nomenclature used here refers specifically to the functional classification of mouse retinal ganglion cells introduced by Baden and colleagues, and is distinct from earlier G-based schemes used for rabbit or other species. Readers should be aware that the same letter–number labels (e.g., "G1", "G2") have been applied in different historical contexts to different animals and criteria (functional vs. morphological), so cross-species or cross-era comparisons of "G" names should not be assumed equivalent without explicit mapping in the primary literature. alpha retinal ganglion cell OFF-t An alpha retinal ganglion cell subtype found in the mouse retina that responds selectively and transiently to decreases in light intensity. It is characterized by a large soma, a broad dendritic arbor that stratifies within sublamina a of the inner plexiform layer, and rapid OFF-transient firing kinetics that decay even during sustained stimulation (Krieger et al., 2017). Functionally, it corresponds to G8 in the Baden functional classification (Baden et al., 2016; Goetz et al., 2022) and C45 in the Tran transcriptomic atlas (Tran et al., 2019), and it is considered the evolutionary ortholog of the primate OFF Parasol RGC (Hahn et al., 2023). This cell type acts as a detector of rapidly approaching dark objects and contributes to innate defensive responses by encoding looming stimuli (Münch et al., 2009). It exhibits a distinctive molecular signature by its expression of Brn3c (Krieger et al., 2017). https://github.com/obophenotype/cell-ontology/issues/3493 GitHub Copilot OFF retinal ganglion cell