part of part of capable of ionocyte ionocyte of salivary gland 2026-03-24T10:46:30Z An ionocyte that is part of a salivary gland, localized to the ductal compartment on the luminal side. This specialized epithelial cell is characterized by expression of FOXI1 and is involved in regulating and maintaining osmotic pressure within the glandular environment (Dong et al., 2024). In normal human salivary glands, FOXI1-positive cells constitute less than 5% of ductal epithelial cells and are found exclusively in ducts, never in acini, across all major gland types including parotid, submandibular, sublingual, and minor salivary glands (Hoki et al., 2024). Like ionocytes in other tissues, this cell is expected to express high levels of CFTR and possess abundant mitochondria and ion transporters. monoatomic ion homeostasis saliva-secreting gland