fibroblast prostate stromal cell fibroblast of connective tissue of nonglandular part of prostate https://cellxgene.cziscience.com/cellguide/CL_1000304 A fibroblast that is part of the connective tissue of nonglandular part of prostate. Fibroblasts of connective tissue of nonglandular part of the prostate, also referred to as prostatic stromal fibroblasts, are specialized cells that are instrumental in maintaining the structure and function of the prostate. These cells constitute a crucial part of the non-glandular or stromal compartment of the prostate, which is composed largely of connective tissue and smooth muscle fibers. Being the most abundant cell type in the prostate stroma, fibroblasts are responsible for the production and maintenance of the extracellular matrix (ECM) via synthesis of collagen and elastin, structural proteins that provides crucial supportive and adhesive framework for the glandular elements of the prostate. These proteins provide tensile strength and elasticity, respectively, contributing to the healthy architecture of the prostate tissue. These cells also play a significant role in coordinating intercellular communication within the prostate by interacting with adjacent epithelial cells, endothelial cells, immune cells, and nerve cells, affecting cell growth, differentiation, and function. Prostatic stromal fibroblasts are actively involved in modulating local immune responses and tissue repair. Acting as local immunomodulatory cells, they can secrete a variety of cytokines and chemokines, influencing the functions of immune cells in the prostate microenvironment. Similarly, under pathological conditions, such as tissue injury or inflammation, these fibroblasts can transition into a more activated state, known as myofibroblasts, driving wound healing and tissue remodeling processes. It's worth noting that aberrant activation and proliferation of these fibroblasts can contribute to pathological situations, such as prostatic hyperplasia and prostate cancer, underscoring their importance in both health and disease. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.) FMA:261281