part of part of epicardial adipocyte adipocyte of epicardial fat of left ventricle An adipocyte that is part of the epicardial fat of left ventricle. Adipocytes of the epicardial fat of the left ventricle are specialized cells localized within the epicardial adipose tissue, which is found enveloping the heart's outer layer, particularly the left ventricle. The primary function of these adipocytes is the storage and release of energy in the form of lipids, which facilitates efficient energy transfer to the myocardium when necessary. They are mesenchymal-derived cells filled with lipid droplets, giving them a unique and distinct appearance when compared to other cell types. The secondary, yet critically important function of these adipocytes revolves around their role as endocrine cells. They're involved in the production and secretion of various bioactive molecules, such as adiponectin, resistin, leptin, cytokines, and other adipocytokines, which play crucial roles in local and systemic metabolism, inflammatory responses, and myocardial protection. Furthermore, these adipocytes serve as a thermal insulation layer for the heart, protecting it from hypothermia and potentially mitigating the risk of arrhythmias caused by abrupt temperature changes. Dysregulation of the adipocytes of the epicardial fat of the left ventricle in their functions can lead to pathological conditions such as obesity, diabetes, and cardiovascular diseases like coronary artery disease and heart failure. For instance, it has been observed that increased volume of epicardial adipose tissue could be linked to the development of coronary atherosclerosis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.) FMA:261300 epicardial fat cell of left ventricle epicardial adipocyte of left ventricle https://cellxgene.cziscience.com/cellguide/CL_1000311 heart left ventricle