part of part of epithelial cell epithelial cell of pancreas epithelial cell of exocrine pancreas An epithelial cell of the exocrine pancreas. exocrine pancreas cell FMA:70986 Epithelial cells of the exocrine pancreas are specialized cells that comprise a vast majority of the pancreas, specifically about 80%. They play a vital role in the digestive system of the body because of their function to produce and secrete digestive enzymes. A subset of these cells, pancreatic acinar and pancreatic ductal cells are organized into functional units termed acini, which in turn form the exocrine pancreas. Here, the produced enzymes are sent down the pancreatic ducts, directly to the duodenum – the first part of the small intestine – aiding in digestion. The exocrine pancreatic epithelial cells are integral in maintaining the body’s metabolism; they function to produce and secrete a variety of pancreatic juices to aid in digestion. The three major enzymes that these cells produce include proteases for protein digestion, amylase for carbohydrate digestion, and lipases for fat digestion. Additionally, these cells secrete bicarbonate ions to neutralize the acidity of the stomach content entering the small intestine, shielding it from acidic damage and ensuring the proper functioning of the digestive enzymes. Dysfunction in the epithelial cells of the exocrine pancreas is linked to common diseases such as pancreatitis, and cancer. Importantly, the regenerative abilities of the pancreas is vital for the pathogenesis of these diseases. Thus, the epithelial cells of the exocrine pancreas are not only critical for routine digestive processes but also have a significant bearing on broader health implications. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.) https://cellxgene.cziscience.com/cellguide/CL_1001433 exocrine pancreas