part of part of epithelial cell of small intestine small intestine secretory cell CALOHA:TS-1286 small bowel glandular cell small intestine glandular cells Small intestine glandular cells play a critical role in the human digestive system. They include various specialized cell types, each with their unique function and are primarily found in the lining of the small intestine, specifically in the crypts of Lieberkühn and the villi. Small intestine glandular cells possess distinct morphological features, such as a brush or microvillus border, which increases their absorptive surface area. Within these microvilli are enzymes that function in the digestion of proteins, carbohydrates, and lipids, breaking them down for easier absorption. The cells are interconnected by tight junctions which ensure that nutrients are selectively and efficiently absorbed while preventing the access of pathogens or harmful substances. In addition to their role in nutrient absorption, small intestine glandular cells also produce and secrete several important substances to facilitate digestion and maintain a healthy gut environment. These include digestive enzymes, mucins for mucous production, and antimicrobial peptides to defend against bacterial invasion. Through these various roles, small intestine glandular cells are essential for sustaining overall health and wellbeing. Their dysfunction has been implicated in a number of gastrointestinal diseases, further highlighting their foundational importance in digestive system biology. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.) https://cellxgene.cziscience.com/cellguide/CL_1001598 FMA:86928 small intestinal glandular cell A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) . secretory epithelial cell epithelium of small intestine small intestine