part of part of glandular secretory epithelial cell adrenal gland glandular cell adrenal glandular cell Adrenal gland glandular cells form the primary functioning cells of the adrenal gland, an endocrine structure that is located superior to the kidneys. These cells are responsible for producing a variety of hormones essential to maintaining daily physiological activities and managing stress reactions. The adrenal gland consists of an outer cortex and an inner medulla, and the adrenal gland glandular cells constitute the predominant cell type of the adrenal cortex. Adrenal gland glandular cells are found in the three layers of the adrenal cortex, each responsible for manufacturing different types of steroid hormones, also known as corticosteroids. The outermost layer, called the zona glomerulosa, mainly produces mineralocorticoids such as aldosterone, which plays a crucial role in regulating the balance of salt and water in the body and maintaining blood pressure. The middle layer, known as the zona fasciculata, primarily produces glucocorticoids, including cortisol. This hormone assists in nutrient metabolism, helps maintain cardiovascular function, and is pivotal in the body's response to stress. Lastly, the inner layer referred to as the zona reticularis, generates a small amount of sex hormones. The adrenal gland glandular cells have a rich blood supply which facilitates the prompt transportation of the synthesized hormones into the bloodstream, from where they are delivered to their target organs. In addition, the production of these hormones is regulated by complex negative feedback mechanisms involving the hypothalamus and pituitary gland in the brain. In response to signals from these brain regions, adrenal gland glandular cells can rapidly adjust the production of hormones to meet the body's requirements during both physiological processes and abnormal or stressful conditions. Any dysfunction of the adrenal gland glandular cells can lead to various disorders such as Cushing's syndrome (overproduction of cortisol) or Addison's disease (insufficient hormone production). (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.) CALOHA:TS-2177 suprarenal gland glandular cell https://cellxgene.cziscience.com/cellguide/CL_1001601 Hormone secreting cell located in the cortex of adrenal gland. Glandular cells in the adrenal cortex secrete mineralocorticoids, glucocorticoids and androgens. adrenal gland glandular cells adrenal cortex