part of part of fibroblast muscle fibroblast Muscle fibroblasts contribute indispensably to the maintenance, repair, and regeneration processes in the muscles tissue of the body. They are a subtype of fibroblasts, which are generally known as the 'builders' of the animal body's extracellular matrix (ECM) and are crucial players in wound healing. Occupying the connective tissues of muscles, muscle fibroblasts partake in the synthesis of the ECM components, including collagen, fibronectin, and laminin, that give the muscle its structure and flexibility. Interestingly, muscle fibroblasts metamorphose functionally during the process of muscle repair following injury. In this circumstance, they react to signals from injured muscle fibers and inflammatory cells, transforming into myofibroblasts. These newly-transformed myofibroblasts showcase contractile properties similar to smooth muscle cells and play a significant role in wound contraction during the healing process while continuing to produce ECM components to ensure reparative scaffolding. Furthermore, muscle fibroblasts secrete various growth factors, primarily those belonging to the 'Transforming Growth Factor-β' (TGF-β) family, to stimulate muscle repair and regulate immune responses. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.) https://cellxgene.cziscience.com/cellguide/CL_1001609 Fibroblast from muscle organ. CALOHA:TS-0643 muscle organ