has soma location has soma location capable of expresses expresses has characterizing marker set NS forest marker set of lamp5 GABAergic interneuron (Human neocortex). interneuron lamp5 GABAergic interneuron The lamp5 GABAergic cortical interneuron, also known as Lamp5 interneuron, is a specialized subtype of cortical interneurons predominantly found in cortical layers of the brain. These cells are principally identified by the expression of the lamp5 gene. This specific subclass of GABAergic cortical interneurons are among five subclasses recently defined for their marker gene expression, which include Sst, Pvalb, Vip, Lamp5, and Sncg. In addition, these interneurons synthesize and release gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, which gives them their GABAergic characteristic. Within the cortical microcircuitry, the lamp5 GABAergic cortical interneurons play crucial roles in modulating neuronal excitability and synaptic transmission. GABA release from these interneurons results in the inhibition of post-synaptic neurons, effectively controlling their activity rates and preventing unchecked excitatory responses, ultimately helping in regulating the balance between excitation and inhibition. This balance is vital for maintaining normal brain functions and its disruption often leads to neuropathological conditions, such as epilepsy and Alzheimer's disease. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.) Lamp5 interneuron https://cellxgene.cziscience.com/cellguide/CL_4023011 ILX:0770149 A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses Lamp5. The marker set LINC00298, KIT can identify the Human cell type lamp5 GABAergic interneuron in the neocortex with a confidence of 0.814687838 (NS-Forest FBeta value). caudal ganglionic eminence derived interneuron gamma-aminobutyric acid secretion, neurotransmission Homo sapiens lysosome-associated membrane glycoprotein 5 cerebral cortex