has soma location has soma location capable of expresses expresses has characterizing marker set NS forest marker set of sst GABAergic interneuron (Human neocortex). sst GABAergic interneuron The marker set SST, PLCH1 can identify the Human cell type sst GABAergic interneuron in the neocortex with a confidence of 0.842367005 (NS-Forest FBeta value). SOM+ inhibitory interneuron A transcriptomically distinct GABAergic neuron located in the cerebral cortex that expresses somatostatin (sst) and derived from the MGE. SST+ IN somatostatin-expressing inhibitory interneuron sst interneuron https://cellxgene.cziscience.com/cellguide/CL_4023017 Sst GABAergic cortical interneuron or somatostatin-expressing GABAergic cortical interneuron, is a type of inhibitory neuron that regulates the activity of other neurons in the cerebral cortex, specifically in the mammalian neocortex. This cell type is named after the inhibitory neurotransmitter it releases, gamma-aminobutyric acid (GABA) and the particular neuropeptide it expresses, somatostatin (sst). Sst GABAergic cortical interneurons make up around 30% of all GABAergic neurons in the cortex and play a critical role in shaping cortical network dynamics and function. This specific subclass of GABAergic cortical interneurons are among five subclasses recently defined for their marker gene expression, which include Sst, Pvalb, Vip, Lamp5, and Sncg. Sst GABAergic cortical interneurons are known for their diverse morphology, axonal projection pattern and electrophysiological properties, but they are most characterized by sst neuropeptide expression. Sst is a hormone that helps regulate the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors. These interneurons typically make synapses onto the dendrites of excitatory pyramidal cells and other interneurons, controlling the input they receive. In doing so, they are primarily responsible for inhibiting and fine-tuning the output of cortical circuits. The function of sst GABAergic cortical interneurons is essential to various cognitive processes, as they play influential roles in controlling the timing and spatial aspects of information processing in the brain. For instance, these cells modulate oscillatory rhythms, a key component of cognition and perception, and help mediate long-range cortico-cortical communication. Interestingly, dysfunctions associated with this cell type have been implicated in several neurological and psychiatric disorders including schizophrenia, autism, and epilepsy. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.) ILX:0770152 medial ganglionic eminence derived GABAergic interneuron gamma-aminobutyric acid secretion, neurotransmission Homo sapiens somatostatin cerebral cortex