expresses expresses macrophage TREM2-positive macrophage 2025-03-17T17:20:08Z TREM2+ macrophage A macrophage characterized by high expression of Triggering Receptor Expressed on Myeloid cells 2 (TREM2), found in various tissues including the liver, adipose tissue, bone, gut (Colonna, 2023), and tumor microenvironments, where it is associated with immunosuppressive and anti-inflammatory activity (Colmenares, 2024; Khantakova, 2022). This cell exhibits a distinct gene expression profile in the tumor microenvironment, including overexpression of complement system genes (C1QA, C1QB, C1QC, C3), and SPP1 in both mice and humans (Xiong, 2020; Khantakova, 2022). It is involved in phagocytosis, tissue repair, and modulation of immune responses (Coeho, 2021). TREM-2 + resident macrophage triggering receptor expressed on myeloid cells 2