expresses expresses CD8-positive, alpha-beta memory T cell granzyme H-associated CD8 T cell 2025-01-10T10:14:31Z This cell type is significantly expanded in systemic lupus erythematosus (SLE) patients. Unlike other CD8 T cell populations, GZMH+ CD8 T cells can comprise up to 50% of all lymphocytes in some SLE patients. granzyme H+ CD8 T cell GZMH+ CD8+ T cell A CD8 T cell characterized by high expression of Granzyme H (GZMH). This cell exhibits a restricted TCR repertoire and elevated expression of cytotoxic, exhaustion, and type I interferon-stimulated gene signatures compared to controls. granzyme H