interneuron neuroendocrine cell adrenocorticotropic hormone secreting cell corticotropin-releasing neuron 2025-07-14T12:17:35Z CRH neuron CRF neuron A specialised type of interneuron defined by the secretion of corticotropin-releasing hormone (CRH), a key peptide in activating the hypothalamic–pituitary–adrenal (HPA) axis during stress. It is primarily located in the paraventricular nucleus (PVN) of the hypothalamus, with additional presence in the hippocampus, piriform area, central amygdalar nucleus, Barrington’s nucleus, and inferior olivary complex (Peng et al., 2017).