in taxon Lamp5 Lhx6 neuron Lamp5 Lhx6 GABAergic interneuron (Homo sapiens) 2025-07-31T14:01:52Z A Lamp5 Lhx6 GABAergic interneuron of Homo sapiens. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: CGE-derived interneurons', Author Categories: 'CrossArea_subclass', Lamp5 Lhx6 Despite being clustered as CGE in this dataset, other studies suggest that the cell is of MGE origin because it expresses transcription factors such as LHX6 and NKX2-1, which are hallmark indicators of MGE-derived interneurons. Fate mapping experiments in mice have demonstrated that Lamp5+/Lhx6+ interneurons in both the hippocampus and neocortex arise from the MGE, and single-cell transcriptomic comparisons further show that primate neocortical Lamp5+/Lhx6+ cells closely resemble mouse hippocampal MGE-derived interneurons rather than classic CGE-derived types. https://cellxgene.cziscience.com/e/e4ddac12-f48f-4455-8e8d-c2a48a683437.cxg/ The marker set CHST9, LAMP5 can identify the Human cell type Lamp5 Lhx6 neuron in the neocortex with a confidence of 0.821678322 (NS-Forest FBeta value). Homo sapiens