in taxon L5 extratelencephalic projecting glutamatergic cortical neuron L5 extratelencephalic projecting glutamatergic cortical neuron (Homo sapiens) 2025-09-16T09:26:37Z pyramidal tract (PT) neuron (Homo sapiens) subcerebral projection (SCPN) neuron (Homo sapiens) A transcriptomically distinct glutamatergic neuron, with a soma found in the deeper portion of L5, that has long-range axonal projections including deep subcortical targets outside of the telencephalon and, in some cases, the spinal cord. While the L5 ET neuron projections are not limited to ET targets, they are clearly differentiated from the neuron subclasses whose projections are constrained to intratelencephalic (IT) targets. L5 ET neurons are generally the largest excitatory cortical neurons, typically having a thick apical dendrite with a prominent dendritic tuft in layer 1 and displaying burst-firing physiological characteristics. The standard transcriptomic reference data for this cell type can be found on the CellxGene census under the collection: 'Transcriptomic cytoarchitecture reveals principles of human neocortex organization', dataset: 'Supercluster: Deep layer (non-IT) excitatory neurons ', Author Categories: 'CrossArea_subclass', clusters L5 ET. burst-firing layer 5 neuron (Homo sapiens) Pyramidal tract-like (PT-l) (Homo sapiens) L5b neuron (Homo sapiens) L5 ET glut (Homo sapiens) The marker set CHST8, POU3F1 can identify the Human cell type L5 extratelencephalic projecting glutamatergic cortical neuron in the neocortex with a confidence of 0.815891473 (NS-Forest FBeta value). thick-tufted layer 5 (TTL5) pyramidal neuron (Homo sapiens) https://orcid.org/0000-0002-5507-2103 Homo sapiens