has soma location has soma location expresses expresses sensory neuron of dorsal root ganglion sacral dorsal root ganglion CGRP neuron 2026-03-13T11:13:54Z A peptidergic nociceptor whose soma is located in the sacral dorsal root ganglion, characterized by expression of calcitonin gene-related peptide (CGRP, encoded by CALCA). This small- to medium-diameter neuron belongs to the TrkA-positive peptidergic subpopulation and typically co-expresses substance P. It innervates peripheral tissues including skin and viscera, where it mediates neurogenic inflammation and nociceptive signalling through release of CGRP from peripheral terminals during tissue injury (Haberberger et al. 2019, PMID:31293388). In human DRG, CGRP-immunoreactive neurons represent a substantial proportion of nociceptors, comparable to the pattern observed in rodents (Rostock et al. 2018, PMID:29229553). peptidergic nociceptor calcitonin gene-related peptide 1 sacral dorsal root ganglion