has soma location has soma location expresses expresses sensory neuron of dorsal root ganglion sacral dorsal root ganglion endothelin-1 neuron 2026-03-13T11:13:54Z sacral dorsal root ganglion Endothelin 1 neuron A sensory neuron whose soma is located in the sacral dorsal root ganglion and that expresses endothelin-1 (EDN1). In rat DRG, EDN1 immunoreactivity has been detected in a subset of neuron somata (Giaid et al. 1989, PMID:2678100). Endothelin-1 acts as an endogenous pain mediator, sensitizing nociceptors through activation of ETA and ETB receptors, and these neurons are implicated in vascular pain signalling. EDN1-expressing DRG neurons have been characterized in rat; their prevalence and properties in human DRG remain to be systematically determined, as EDN1 is not yet represented in human DRG single-cell transcriptomic datasets. EDN1 neuron endothelin-1 sacral dorsal root ganglion