has soma location has soma location expresses expresses sensory neuron of dorsal root ganglion sacral dorsal root ganglion peripherin neuron 2026-03-13T11:13:54Z A small-diameter sensory neuron whose soma is located in the sacral dorsal root ganglion and that expresses peripherin (encoded by PRPH), a type III intermediate filament protein. This neuron is unmyelinated, conducts action potentials as a C-fiber, and encompasses nociceptive and thermoceptive functional subpopulations. In human DRG, peripherin-immunoreactive neurons are predominantly of small diameter (Chang et al. 2018, PMID:28424991), distinguishing them from large-diameter myelinated A-fiber neurons that instead express neurofilament heavy chain (Haberberger et al. 2019, PMID:31293388). In mice, peripherin similarly marks unmyelinated primary afferent neurons. sacral dorsal root ganglion Peripherin neuron C-fiber neuron peripherin sacral dorsal root ganglion