has soma location has soma location expresses expresses sensory neuron of dorsal root ganglion sacral dorsal root ganglion Piezo2 neuron 2026-03-13T11:13:54Z A mechanosensitive sensory neuron whose soma is located in the sacral dorsal root ganglion and that expresses the mechanically activated ion channel Piezo2 (encoded by PIEZO2). This neuron transduces mechanical stimuli and is involved in light touch perception and proprioception. In human DRG, Piezo2-immunoreactive neurons constitute approximately 35% of TrkA-positive neurons, compared to 26% in mouse (Rostock et al. 2018, PMID:29229553). This subpopulation includes both low-threshold mechanoreceptors mediating innocuous touch and a subset of mechanically sensitive nociceptors, reflecting the dual role of Piezo2 in somatosensation across species. mechanosensitive DRG neuron piezo-type mechanosensitive ion channel component 2 sacral dorsal root ganglion