part of part of results in morphogenesis of anatomical structure morphogenesis midbrain-hindbrain boundary morphogenesis isthmus morphogenesis The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. MHB morphogenesis biological_process GO:0021555 midbrain-hindbrain boundary development embryonic morphogenesis midbrain-hindbrain boundary