transient receptor potential cation channel TRPV Category=family. fam:TRPV PR:000000681 PIRSF:PIRSF038527 protein A transient receptor potential channel protein that is a member of the subfamily V of the transient receptor potential cation channels (TRPs), with amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. The amino-terminal domain contains up to 6 copies of detectable ankyrin repeat (Pfam:PF00023). Most TRPs are relatively non-selective. They may be modulated by voltage changes but channel gating is generally effected by other means. transient receptor potential channel protein