part of part of overlaps Mammalia hepatic acinus hepatic acinus zone 3 The region of the hepatic acinus immediately surrounding the central veins. This region has the lowest oxygen concentration in the acinus. Zone 3 is located in the centrilobular region of the liver lobule, closest to the central vein. Hepatocytes in this region are the primary location for the biotransformation of drugs. UBERON:8400002 2020-09-08T15:05:03Z hepatic acinus perivenous zone hepatic acinus centrilobular zone hepatic acinus pericentral zone metabolic zone of liver liver lobule centrilobular region