chemical entity 化学实体 latrunculin A 拉春库林A (+)-latrunculin A (4R)-4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-1,3-thiazolidin-2-one (4R)-4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-1,3-thiazolidin-2-one 0 421.192 421.55000 A bicyclic macrolide natural product consisting of a 16-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica and from the Fiji Islands sponge Cacospongia mycofijiensis. Latrunculin A inhibits actin polymerisation, microfilament organsation and microfilament-mediated processes. C22H31NO5S CAS:76343-93-6 CHEBI:43626 CHEBI:69136 DDVBPZROPPMBLW-IZGXTMSKSA-N InChI=1S/C22H31NO5S/c1-15-7-5-3-4-6-8-16(2)11-20(24)27-18-12-17(10-9-15)28-22(26,13-18)19-14-29-21(25)23-19/h3-5,7,11,15,17-19,26H,6,8-10,12-14H2,1-2H3,(H,23,25)/b4-3+,7-5-,16-11-/t15-,17-,18-,19+,22-/m1/s1 LAT-A LATRUNCULIN A LatA NSC 613011 PDBeChem:LAR PMID:10859320 PMID:12087066 PMID:17897856 PMID:19528469 PMID:20677927 PMID:22492972 PMID:22498812 PMID:3200109 PMID:3556584 PMID:9250716 Reaxys:4239363 [H][C@]1(CSC(=O)N1)[C@@]1(O)C[C@H]2C[C@@H](CC[C@H](C)\C=C/C=C/CC\C(C)=C/C(=O)O2)O1 chebi_ontology (+)-拉春库林A 一种双环大环内酯类天然产物，由一种十六元的双环内酯，附在罕见的2-噻唑酮中形成。它是取自红海海绵Latrunculia magnifica和斐济群岛海绵Cacospongia mycofijiensis。微丝解聚剂抑制肌动蛋白聚合，微丝组织和微丝介导的过程。 拉春库林A