<?xml version="1.0"?>
<?xml-stylesheet type="text/xsl" href="https://ontobee.org/ontology/view/CLO-NICR?iri=http://www.ebi.ac.uk/efo/EFO_0000621"?>
<rdf:RDF xmlns="http://www.w3.org/2002/07/owl#"
     xml:base="http://www.w3.org/2002/07/owl"
     xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
     xmlns:owl="http://www.w3.org/2002/07/owl#"
     xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
     xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:foaf="http://xmlns.com/foaf/0.1/"
     xmlns:dc="http://purl.org/dc/elements/1.1/"
     xmlns:ns3="http://purl.obolibrary.org/obo/"
     xmlns:efo="http://www.ebi.ac.uk/efo/">
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotation properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000118"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000117"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000119"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000412"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Datatypes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Object Properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://www.ebi.ac.uk/efo/EFO_0000784 -->

    <ObjectProperty rdf:about="http://www.ebi.ac.uk/efo/EFO_0000784">
        <rdfs:label xml:lang="en">has_disease_location</rdfs:label>
    </ObjectProperty>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Classes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/DOID_2622 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/DOID_2622">
        <rdfs:label xml:lang="en">neuroblastic tumor</rdfs:label>
        <rdfs:label xml:lang="zh">神经母细胞性肿瘤</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/DOID_4158 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/DOID_4158">
        <rdfs:label xml:lang="en">Ewings sarcoma-primitive neuroectodermal tumor (PNET)</rdfs:label>
        <rdfs:label xml:lang="zh">尤文氏肉瘤-原始神经外胚层肿瘤（PNET）</rdfs:label>
    </Class>
    


    <!-- http://www.ebi.ac.uk/efo/EFO_0000621 -->

    <Class rdf:about="http://www.ebi.ac.uk/efo/EFO_0000621">
        <rdfs:label xml:lang="en">neuroblastoma</rdfs:label>
        <rdfs:label xml:lang="zh">神经母细胞瘤</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DOID_2622"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DOID_4158"/>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://www.ebi.ac.uk/efo/EFO_0000784"/>
                <someValuesFrom rdf:resource="http://www.ebi.ac.uk/efo/EFO_0000893"/>
            </Restriction>
        </rdfs:subClassOf>
        <ns3:IAO_0000118 xml:lang="en">(Neuroblastoma NOS) or (sympathicoblastoma)</ns3:IAO_0000118>
        <rdfs:comment xml:lang="en">A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome (MeSH).</rdfs:comment>
        <rdfs:comment xml:lang="en">A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)</rdfs:comment>
        <rdfs:comment xml:lang="en">A neuroblastic tumor characterized by the presence of neuroblastic cells, the absence of ganglion cells, and the absence of a prominent Schwannian stroma formation.</rdfs:comment>
        <ns3:IAO_0000118 xml:lang="en">Central neuroblastoma</ns3:IAO_0000118>
        <ns3:IAO_0000119 xml:lang="en">DOID:769</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:11705866</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:11737230</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:11744098</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:11782392</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:11807986</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:11836564</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:11859407</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:11861392</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:11870543</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:11877670</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:11877677</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:11881792</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:11928813</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:12031683</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:12085233</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:12118090</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:12154078</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:12163469</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:12174591</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:12185581</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:12209604</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:12239177</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:12438307</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:12545167</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:12557224</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:12576454</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:12593854</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:12598334</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:12629151</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:12629521</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:12647219</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:12672031</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:12675130</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:12717420</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:12808116</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:12829373</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:12884264</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:12888911</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:12907629</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:12916719</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:12962147</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:12964007</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:13679866</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:14645238</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:14654552</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:14663483</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:14719101</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:14724587</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:14745549</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:14988008</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:14995074</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15004408</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15015775</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15024693</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15083193</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15117961</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15136145</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15166121</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15168079</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15218241</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15240516</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15280446</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15316056</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15322424</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15328517</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15375504</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15448191</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15486895</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15488758</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15514946</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15516980</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15518890</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15547663</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15607966</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15618969</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15644444</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15650242</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15719172</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15735700</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15741235</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15827327</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15849504</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15882878</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15930276</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15994346</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:15998644</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:16007146</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:16051641</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:16091745</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:16092940</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:16098972</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:16125842</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:16166307</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:16177824</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:16228012</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">GeneRIF:16232196</ns3:IAO_0000119>
        <ns3:IAO_0000117 xml:lang="en">James Malone</ns3:IAO_0000117>
        <ns3:IAO_0000119 xml:lang="en">MSH:D009447</ns3:IAO_0000119>
        <ns3:IAO_0000118 xml:lang="en">NB - Neuroblastoma</ns3:IAO_0000118>
        <ns3:IAO_0000119 xml:lang="en">NCIt:C3270</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">NIFSTD:birnlex_12631</ns3:IAO_0000119>
        <ns3:IAO_0000118 xml:lang="en">Neuroblastoma (Schwannian Stroma-Poor)</ns3:IAO_0000118>
        <ns3:IAO_0000118 xml:lang="en">Neuroblastoma, NOS</ns3:IAO_0000118>
        <ns3:IAO_0000118 xml:lang="en">Neuroblastomas</ns3:IAO_0000118>
        <ns3:IAO_0000119 xml:lang="en">SNOMEDCT:269507008</ns3:IAO_0000119>
        <ns3:IAO_0000119 xml:lang="en">SNOMEDCT:87364003</ns3:IAO_0000119>
        <ns3:IAO_0000118 xml:lang="en">Sympathicoblastoma</ns3:IAO_0000118>
        <ns3:IAO_0000117 xml:lang="en">Tomasz Adamusiak</ns3:IAO_0000117>
        <rdfs:seeAlso xml:lang="en">URI: http://www.ebi.ac.uk/cellline#neuroblastoma</rdfs:seeAlso>
        <ns3:IAO_0000118 xml:lang="en">[M]Neuroblastoma NOS</ns3:IAO_0000118>
        <ns3:IAO_0000118 xml:lang="en">[M]Neuroblastoma NOS (morphologic abnormality)</ns3:IAO_0000118>
        <ns3:IAO_0000118 xml:lang="en">neuroblastoma</ns3:IAO_0000118>
        <ns3:IAO_0000118 xml:lang="en">neuroblastoma (morphologic abnormality)</ns3:IAO_0000118>
        <ns3:IAO_0000118 xml:lang="en">neuroblastoma NOS (morphologic abnormality)</ns3:IAO_0000118>
        <ns3:IAO_0000118 xml:lang="zh">NB-神经母细胞瘤</ns3:IAO_0000118>
        <ns3:IAO_0000118 xml:lang="zh">[M]神经母细胞瘤NOS</ns3:IAO_0000118>
        <ns3:IAO_0000118 xml:lang="zh">[M]神经母细胞瘤NOS（形态异常）</ns3:IAO_0000118>
        <ns3:IAO_0000118 xml:lang="zh">中枢神经母细胞瘤</ns3:IAO_0000118>
        <ns3:IAO_0000118 xml:lang="zh">成交感神经细胞瘤</ns3:IAO_0000118>
        <ns3:IAO_0000118 xml:lang="zh">成神经细胞瘤（形态异常）</ns3:IAO_0000118>
        <rdfs:comment xml:lang="zh">早产儿常见的肿瘤来源于交感神经系统的神经嵴细胞，具有不同的临床表现，从自发缓解到快速转移进展和死亡。这种肿瘤是儿童时期最常见的腹腔内恶性肿瘤，但也可能起源于胸部，颈部或罕见的中枢神经系统。组织学特征包括均匀的圆形细胞，在巢中排列有多色核，并通过纤维血管间隔分开。神经母细胞瘤可能与眼球阵挛-肌阵挛综合征（MeSH）有关。</rdfs:comment>
        <rdfs:comment xml:lang="zh">早产儿常见的肿瘤来源于交感神经系统的神经嵴细胞，具有不同的临床表现，从自发缓解到快速转移进展和死亡。这种肿瘤是儿童时期最常见的腹腔内恶性肿瘤，但也可能起源于胸部，颈部或罕见的中枢神经系统。组织学特征包括均匀的圆形细胞，在巢中排列有多色核，并通过纤维血管间隔分开。神经母细胞瘤可能与眼球阵挛-肌阵挛综合征（MeSH）有关。（DeVita等人，Cancer：Principles and Practice of Oncology，5th ed，pp2099-2101; Curr Opin Oncol 1998 Jan; 10（1）：43-51）</rdfs:comment>
        <ns3:IAO_0000118 xml:lang="zh">神经母细胞瘤</ns3:IAO_0000118>
        <ns3:IAO_0000118 xml:lang="zh">神经母细胞瘤 (Schwannian Stroma-Poor)</ns3:IAO_0000118>
        <ns3:IAO_0000118 xml:lang="zh">神经母细胞瘤(Neuroblastomas)</ns3:IAO_0000118>
        <ns3:IAO_0000118 xml:lang="zh">神经母细胞瘤NOS（形态异常）</ns3:IAO_0000118>
        <rdfs:comment xml:lang="zh">神经母细胞瘤的特征是神经母细胞的出现，神经节细胞的缺失以及没有明显的Schwannian基质形成。</rdfs:comment>
        <ns3:IAO_0000118 xml:lang="zh">神经母细胞瘤，NOS</ns3:IAO_0000118>
        <ns3:IAO_0000118 xml:lang="zh">（成神经细胞瘤NOS）或（交感神经细胞瘤）</ns3:IAO_0000118>
        <ns3:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/clo.owl"/>
    </Class>
    


    <!-- http://www.ebi.ac.uk/efo/EFO_0000893 -->

    <Class rdf:about="http://www.ebi.ac.uk/efo/EFO_0000893">
        <rdfs:label xml:lang="en">sympathetic nervous system</rdfs:label>
        <rdfs:label xml:lang="zh">交感神经系统</rdfs:label>
    </Class>
</rdf:RDF>



<!-- Generated by the OWL API (version 3.2.4.1806) http://owlapi.sourceforge.net -->



