<?xml version="1.0"?>
<?xml-stylesheet type="text/xsl" href="https://ontobee.org/ontology/view/CLO?iri=http://purl.obolibrary.org/obo/CL_0000129"?>
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     xml:base="http://www.w3.org/2002/07/owl"
     xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
     xmlns:owl="http://www.w3.org/2002/07/owl#"
     xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
     xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:foaf="http://xmlns.com/foaf/0.1/"
     xmlns:dc="http://purl.org/dc/elements/1.1/"
     xmlns:ns3="http://purl.obolibrary.org/obo/">
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotation properties
    //
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    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasOBONamespace"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000412"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasDbXref"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Datatypes
    //
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    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Object Properties
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    <!-- http://purl.obolibrary.org/obo/BFO_0000050 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000050">
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <rdfs:label>part_of</rdfs:label>
        <rdfs:label>part of</rdfs:label>
        <rdfs:label xml:lang="en">part of</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002104 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002104">
        <rdfs:label xml:lang="en">has plasma membrane part</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002202 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002202">
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <rdfs:label>develops_from</rdfs:label>
        <rdfs:label xml:lang="en">develops from</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002215 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002215">
        <rdfs:label>capable of</rdfs:label>
        <rdfs:label xml:lang="en">capable of</rdfs:label>
    </ObjectProperty>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Classes
    //
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     -->

    


    <!-- http://purl.obolibrary.org/obo/CARO_0000006 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CARO_0000006">
        <rdfs:label>material anatomical entity</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CL_0000125 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CL_0000125">
        <rdfs:label>glial cell</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CL_0000129 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CL_0000129">
        <rdfs:label>microglial cell</rdfs:label>
        <equivalentClass>
            <Class>
                <intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/CL_0000125"/>
                    <Restriction>
                        <onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                        <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/UBERON_0001017"/>
                    </Restriction>
                    <Restriction>
                        <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002104"/>
                        <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PR_000001012"/>
                    </Restriction>
                    <Restriction>
                        <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002104"/>
                        <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PR_000001813"/>
                    </Restriction>
                    <Restriction>
                        <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002104"/>
                        <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PR_000002064"/>
                    </Restriction>
                    <Restriction>
                        <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002215"/>
                        <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0045087"/>
                    </Restriction>
                </intersectionOf>
            </Class>
        </equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CARO_0000006"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CL_0000125"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CL_0000878"/>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002104"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PR_000002064"/>
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        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002104"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PR_000001012"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002104"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PR_000001813"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002215"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0045087"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002202"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CL_0002453"/>
            </Restriction>
        </rdfs:subClassOf>
        <oboInOwl:hasOBONamespace>cell</oboInOwl:hasOBONamespace>
        <ns3:IAO_0000115>A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive.</ns3:IAO_0000115>
        <oboInOwl:hasDbXref>FMA:54539</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>microglia</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>BTO:0000078</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>MF.microglia.CNS</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasExactSynonym>hortega cells</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>brain-resident macrophage</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>BTO:0000962</oboInOwl:hasDbXref>
        <oboInOwl:hasBroadSynonym>brain macrophage</oboInOwl:hasBroadSynonym>
        <rdfs:comment>Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive.</rdfs:comment>
        <oboInOwl:hasExactSynonym>microgliocyte</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>FMA:54540</oboInOwl:hasDbXref>
        <ns3:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/cl.owl"/>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CL_0000878 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CL_0000878">
        <rdfs:label>central nervous system macrophage</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CL_0002453 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CL_0002453">
        <rdfs:label>oligodendrocyte precursor cell</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/GO_0045087 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/GO_0045087">
        <rdfs:label>innate immune response</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/PR_000001012 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/PR_000001012">
        <rdfs:label>integrin alpha-M</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/PR_000001813 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/PR_000001813">
        <rdfs:label>adhesion G protein-coupled receptor E1</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/PR_000002064 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/PR_000002064">
        <rdfs:label>macrosialin</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/UBERON_0001017 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/UBERON_0001017">
        <rdfs:label>central nervous system</rdfs:label>
    </Class>
</rdf:RDF>



<!-- Generated by the OWL API (version 3.2.4.1806) http://owlapi.sourceforge.net -->



