Leigh disease NCI:C84814 MESH:D007888 GARD:6877 SNOMEDCT_US_2025_09_01:29570005 ORDO:506 ICD10CM:G31.82 DOID:3652 UMLS_CUI:C0023264 A cytochrome-c oxidase deficiency disease characterized by progressive loss of mental and movement abilities. Symptoms usually begin between ages of three months and two years and include loss of appetite, vomiting, irritability and seizure activity. Infantile necrotizing encephalomyelopathy Leigh syndrome disease_ontology MIM:256000 Xref MGI. OMIM mapping confirmed by DO. [SN]. juvenile subacute necrotizing encephalomyelopathy subacute necrotizing encephalomyelopathy inherited metabolic disorder