simple genetic disease Cockayne syndrome Cockayne Syndrome, Type II Type III Cockayne Syndrome Cokayne syndrome Cockayne Syndrome Type 3 Cockayne's syndrome SNOMEDCT:21086008 Cockayne Syndrome, Group C Cockayne Syndrome, Group B Progeria-Like Syndromes DOID:2962 An autosomal recessive syndrome caused by mutations in the ERCC8 and ERCC6 genes. It is characterized by growth and developmental delay, vision and hearing impairment, and impairment of the peripheral nervous system function. Type A Cockayne Syndrome Caused by mutations of gene ERCC6. Cockayne syndrome (disorder) Cockayne Syndrome Type C Type I Cockayne Syndrome GeneRIF:16246722 A simple genetic disease that is caused by a rare autosomal recessive mutations in two DNA excision repair proteins, ERCC-8 and ERCC-6, and characterized by growth failure, impaired development of the nervous system, abnormal sensitivity to sunlight (photosensitivity), and premature aging. Group A Cockayne Syndrome GeneRIF:12095617 Cockayne Syndrome, Type B Progeria-Like Syndrome James Malone A syndrome characterized by multiple system abnormalities including DWARFISM; PHOTOSENSITIVITY DISORDERS; PREMATURE AGING; and HEARING LOSS. It is caused by mutations of a number of autosomal recessive genes encoding proteins that involve transcriptional-coupled DNA REPAIR processes. Cockayne syndrome is classified by the severity and age of onset. Type I (classical; CSA) is early childhood onset in the second year of life; type II (congenital; CSB) is early onset at birth with severe symptoms; type III (xeroderma pigmentosum; XP) is late childhood onset with mild symptoms. Caused by mutations of gene CKN1. URI: http://www.ebi.ac.uk/cellline#cockayne_syndrome cockayne syndrome GeneRIF:11809892 MSH:D003057 NCIt:C9460 GeneRIF:15082767 GeneRIF:12748643 Dwarfism-retinal atrophy-deafness syndrome Type C is a rare form. Its genetic defect is not clear; appears to be a heterogeneous group. OMIM suggests that Type C should not be used anymore.