disease severity measurement infection severity measurement 2013-10-15T14:50:35Z Any measurement of the degree to which the presentation of an infection has caused pain or damage, or of the degree to which an infectious agent (e.g., bacteria, virus or parasite) has established lesions or infectious colonies, and/or taken over or interfered with the normal functioning of the body as a whole, or of one or more organs, tissues, cells or subcellular mechanisms of an organism. An infection is invasion and multiplication of microorganisms such as bacteria, viruses, or parasites in body tissues, especially that causing local cellular injury due to competitive metabolism, toxins, intracellular replication, or antigen-antibody response. CMO:0001825 JSmith clinical_measurement_ontology