disease severity measurement colonic aganglionosis severity measurement 2013-10-15T18:03:27Z Any measurement of the degree to which the presentation of colonic aganglionosis has caused pain or damage, established lesions, and/or interfered with the normal functioning of the colon, the segment of the large intestine between the cecum and the rectum. Colonic aganglionosis is the absence of parasympathetic ganglion cells in any or all of the myenteric plexus, a network of autonomic nerve fibers within the tunica muscularis of the wall of the alimentary canal in general and of the colon in particular. CMO:0001834 Hirschsprung's disease severity measurement JSmith MESH:D006627 clinical_measurement_ontology intestinal aganglionosis severity measurement