calculated blood vessel dilation force reduction measurement BAY60-4552 response/sensitivity measurement concentration of BAY 60-4552 at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) 2020-05-15T13:02:00Z A calculated value for the concentration of BAY 60-4552, a small molecule stimulator of soluble guanylate cyclase, at which the energy exerted during the active expansion in the diameter of a blood vessel in response to the application of BAY 60-4552 is halfway between the highest value, that is the force at greatest constriction (often measured in a pre-constricted blood vessel), and the lowest achievable value of such contractile energy during BAY 60-4552-induced relaxation of the vessel wall (i.e. the maximum effect of BAY 60-4552 which is the minimum contractile energy). CMO:0003413 PMID:22783192 VT:0000197 clinical_measurement_ontology concentration of Nelociguat at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) slaulede