has participant quality necrosis AE AE severity G1 AE severity G2 AE severity G3 AE severity G4 AE severity G5 avascular necrosis AE 10066480 MW, YH a necrosis AE that has necrotic changes in the bone tissue due to interruption of blood supply. Most often affecting the epiphysis of the long bones, the necrotic changes result in the collapse and the destruction of the bone structure. CTCAE: E12382 NCIt: C34880