has participant quality AE severity G2 AE severity G3 AE severity G4 AE severity G5 appendicitis AE appendicitis perforated AE 10003012 CTCAE: E11296 NCIt: C78178 an appendicitis AE that has acute inflammation to the vermiform appendix caused by a pathogenic agent with gangrenous changes resulting in the rupture of the appendiceal wall. The appendiceal wall rupture causes the release of inflammatory and bacterial contents from the appendiceal lumen into the abdominal cavity. MW, YH