is about drug-drug interaction mechanism of interaction information An assertion about the process or the processes by which a drug-drug interaction clinical consequence occurs. An information content entity that represents a drug interaction as a directional series of molecular processes. An instance of this entity would represent the biochemical process by which pharmacokinetic or pharmacodynamic DDI is thought to occur. Non-steroidal anti-inflammatory drugs (NSAIDs) have antiplatelet effects which increase the bleeding risk when combined with oral anticoagulants such as warfarin. The antiplatelet effect of NSAIDs lasts only as long as the NSAID is present in the circulation, unlike aspirin’s antiplatelet effect, which lasts for up to 2 weeks after aspirin is discontinued. This is an information content entity that is about a clinically measurable drug-drug interaction. Timolol is a nonselective beta-blocker, and timolol eye drops have been shown to produce systemic beta-blockade. Timolol is metabolized by CYP2D6, and patients who are deficient in CYP2D6 (PMs) have been shown to develop higher timolol plasma concentrations following timolol ophthalmic aqueous drops. drug interaction mechanism information content entity