<?xml version="1.0"?>
<?xml-stylesheet type="text/xsl" href="https://ontobee.org/ontology/view/DIDEO?iri=http://purl.obolibrary.org/obo/DIDEO_00000066"?>
<rdf:RDF xmlns="http://www.w3.org/2002/07/owl#"
     xml:base="http://www.w3.org/2002/07/owl"
     xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
     xmlns:owl="http://www.w3.org/2002/07/owl#"
     xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
     xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:foaf="http://xmlns.com/foaf/0.1/"
     xmlns:dc="http://purl.org/dc/elements/1.1/"
     xmlns:ns3="http://purl.obolibrary.org/obo/">
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotation properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000118"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000117"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000119"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Datatypes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Object Properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/BFO_0000050 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000050">
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <rdfs:label xml:lang="en">part of</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/BFO_0000055 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/BFO_0000055">
        <rdfs:label xml:lang="en">realizes</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/IAO_0000136 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000136">
        <rdfs:label xml:lang="en">is about</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000293 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/OBI_0000293">
        <rdfs:label xml:lang="en">has_specified_input</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0000053 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000053">
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#InverseFunctionalProperty"/>
        <rdfs:label xml:lang="en">bearer of</rdfs:label>
        <rdfs:label xml:lang="en">has characteristic</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0000056 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000056">
        <rdfs:label xml:lang="en">participates in</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0000057 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000057">
        <rdfs:label xml:lang="en">has participant</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0000059 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000059">
        <rdfs:label xml:lang="en">concretizes</rdfs:label>
    </ObjectProperty>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Classes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/CHEBI_25212 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_25212">
        <rdfs:label>metabolite</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_35222 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35222">
        <rdfs:label>inhibitor</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_38559 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_38559">
        <rdfs:label>cytochrome P450</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_59999 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999">
        <rdfs:label>chemical substance</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CLO_0000031 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CLO_0000031">
        <rdfs:label xml:lang="en">cell line</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/DIDEO_00000053 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053">
        <rdfs:label xml:lang="en">evidence information content entity</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/DIDEO_00000066 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000066">
        <rdfs:label xml:lang="en">evidence information from CYP450 recombinant drug metabolism identification experiment using antibody inhibitors</rdfs:label>
        <equivalentClass>
            <Class>
                <intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
                    <Restriction>
                        <onProperty rdf:resource="http://purl.obolibrary.org/obo/IAO_0000136"/>
                        <someValuesFrom>
                            <Class>
                                <intersectionOf rdf:parseType="Collection">
                                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/OBI_0000070"/>
                                    <Restriction>
                                        <onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000055"/>
                                        <someValuesFrom>
                                            <Restriction>
                                                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000059"/>
                                                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0001285"/>
                                            </Restriction>
                                        </someValuesFrom>
                                    </Restriction>
                                    <Restriction>
                                        <onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
                                        <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CLO_0000031"/>
                                    </Restriction>
                                    <Restriction>
                                        <onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
                                        <someValuesFrom>
                                            <Class>
                                                <intersectionOf rdf:parseType="Collection">
                                                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/CHEBI_59999"/>
                                                    <Class>
                                                        <unionOf rdf:parseType="Collection">
                                                            <Restriction>
                                                                <onProperty rdf:resource="http://purl.obolibrary.org/obo/BFO_0000050"/>
                                                                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/DRON_00000005"/>
                                                            </Restriction>
                                                            <Restriction>
                                                                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
                                                                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25212"/>
                                                            </Restriction>
                                                        </unionOf>
                                                    </Class>
                                                    <Restriction>
                                                        <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000056"/>
                                                        <someValuesFrom>
                                                            <Class>
                                                                <intersectionOf rdf:parseType="Collection">
                                                                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0008152"/>
                                                                    <Restriction>
                                                                        <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000057"/>
                                                                        <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_38559"/>
                                                                    </Restriction>
                                                                </intersectionOf>
                                                            </Class>
                                                        </someValuesFrom>
                                                    </Restriction>
                                                </intersectionOf>
                                            </Class>
                                        </someValuesFrom>
                                    </Restriction>
                                    <Restriction>
                                        <onProperty rdf:resource="http://purl.obolibrary.org/obo/OBI_0000293"/>
                                        <someValuesFrom>
                                            <Class>
                                                <intersectionOf rdf:parseType="Collection">
                                                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/GO_0042571"/>
                                                    <Restriction>
                                                        <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000053"/>
                                                        <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35222"/>
                                                    </Restriction>
                                                </intersectionOf>
                                            </Class>
                                        </someValuesFrom>
                                    </Restriction>
                                </intersectionOf>
                            </Class>
                        </someValuesFrom>
                    </Restriction>
                </intersectionOf>
            </Class>
        </equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DIDEO_00000053"/>
        <ns3:IAO_0000115 xml:lang="en">An evidence information content entity that is about an in vitro assay that has a part of a drug or a drug metabolite, which participate in a metabolic process that has CYP 450 as a participant, as a specified input, and that has human tissue specimen as a specified input, and that has antibody inhibitors as a specified input.</ns3:IAO_0000115>
        <ns3:IAO_0000118 xml:lang="en">EV_EX_Met_Enz_ID_Cyp450_Hum_Recom_Antibody</ns3:IAO_0000118>
        <ns3:IAO_0000117 xml:lang="en">Mathias Brochhausen</ns3:IAO_0000117>
        <ns3:IAO_0000119 xml:lang="en">https://dbmi-icode-01.dbmi.pitt.edu/dikb-evidence/just-inclusion-criteria/just-inclusion-criteria.html</ns3:IAO_0000119>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/DRON_00000005 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/DRON_00000005">
        <rdfs:label xml:lang="en">drug product</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/GO_0008152 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/GO_0008152">
        <rdfs:label>metabolic process</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/GO_0042571 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/GO_0042571">
        <rdfs:label>immunoglobulin complex, circulating</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0000070 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/OBI_0000070">
        <rdfs:label xml:lang="en">assay</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/OBI_0001285 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/OBI_0001285">
        <rdfs:label xml:lang="en">in vitro design</rdfs:label>
    </Class>
</rdf:RDF>



<!-- Generated by the OWL API (version 3.2.4.1806) http://owlapi.sourceforge.net -->



