DO_rare_slim has material basis in has phenotype has symptom disease has location 3-methylcrotonyl-CoA carboxylase deficiency DOID:0050710 ORDO:6 disease_ontology 2012-05-22T10:32:44Z 3-Methylcrotonylglycinuria 3MCC deficiency An amino acid metabolic disorder that is classified by inadequate levels of the enzyme 3-methylcrotonyl-CoA carboxylase that helps break down proteins containing the amino acid leucine. This disease has_symptom muscular hypotonia (weak muscle tone), has_symptom muscular atrophy, has_symptom feeding difficulties, has_symptom recurrent episodes of vomiting and diarrhea, and has_symptom lethargy. BMCC deficiency MIM:PS210200 GARD:10954 autosomal recessive disease muscular disease amino acid metabolic disorder autosomal recessive inheritance Hypotonia Skeletal muscle atrophy lethargy poor feeding diarrhea vomiting muscle tissue