has material basis in methylmalonic aciduria and homocystinuria type cblC DOID:0050715 MIM:277400 2012-05-23T03:26:25Z disease_ontology A methylmalonic acidemia that has_material_basis_in deficiency in synthesis of both AdoCbl and MeCbl (cblC) and is characterized by decreased levels of the coenzymes adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl), which results in decreased activity of the respective enzymes methylmalonyl-CoA mutase. Cobalamin C deficiency MAHCC digenic disease methylmalonic acidemia digenic inheritance