has material basis in disease has basis in autosomal recessive disease corneal endothelial dystrophy congenital hereditary endothelial dystrophy of cornea MIM:217700 A corneal endothelial dystrophy that has_material_basis_in homozygous or compound heterozygous mutation in the SLC4A11 gene, which encodes a sodium borate cotransporter, on chromosome 20p13 and is characterized by thickening and opacification of the cornea, altered morphology of the endothelium, and secretion of an abnormal collagenous layer at the Descemet membrane. DOID:0060649 CHED disease_ontology physical disorder autosomal recessive inheritance Abnormality of prenatal development or birth