DO_rare_slim has material basis in autosomal dominant disease generalized severe epidermolysis bullosa simplex 1A ICD10CM:Q81.0 disease_ontology MIM:131760 DOID:0060735 An epidermolysis bullosa simplex characterized by generalized non-scarring skin blistering that often occurs in clusters, progressive hyperkeratosis of the palms and soles, clumping of keratin filaments in basal epidermal cells and that has_material_basis_in mutation in the Keratin 14 (KRT14) gene on chromosome 17q21 either the KRT5 or KRT14 genes. This is the most severe of the epidermolysis bullosa simplex types and may result in neonatal or infant lethality in some cases. EBS-gen sev EBSDM ORDO:79396 epidermolysis bullosa herpetiformis Dowling-Meara type epidermolysis bullosa simplex Dowling-Meara type epidermolysis bullosa simplex, herpetiformis generalized severe epidermolysis bullosa simplex epidermolysis bullosa simplex autosomal dominant inheritance