DO_rare_slim NCIthesaurus immunodeficiency with hyper-IgM type 4 MESH:C564277 UMLS_CUI:C1842413 GARD:10580 MIM:608184 MIM:608184 GARD:10580 DOID:0060760 A hyper IgM syndrome that is characterized by normal or increased serum IgM concentrations associated with low or absent serum IgG, IgA, and IgE concentrations, indicating a defect in the class-switch recombination (CSR) process. UMLS_CUI:C1842413 ORDO:101091 disease_ontology MESH:C564277 ORDO:101091 ORDO:183666 HIGM4 hyper-IgM syndrome type 4 hyper IgM syndrome