DO_rare_slim restrictive dermopathy A skin disease characterized by thin, tightly adherent translucent skin with erosions at flexure sites, superficial vessels, typical facial dysmorphism, and generalized joint ankylosis. Prenatal signs may include intrauterine growth retardation, reduced fetal movements, polyhydramnios, and premature rupture of the membranes. Most infants die within the first week of life. UMLS_CUI:C0406585 GARD:1516 SNOMEDCT_US_2023_02_28:400128006 MIM:PS275210 UMLS_CUI:C0406585 SNOMEDCT_US_2025_09_01:400128006 GARD:1516 Infantile restrictive dermopathy Lethal tight skin contracture syndrome MIM:PS275210 MESH:C536920 disease_ontology ORDO:1662 DOID:0060762 ORDO:1662 MESH:C536920 hyperkeratosis-contracture syndrome lethal restrictive dermopathy tight skin contracture syndrome skin disease