DO_rare_slim has material basis in existence starts during autosomal dominant disease adult onset demyelinating leukodystrophy typical adult-onset autosomal dominant demyelinating leukodystrophy ADLD disease_ontology GARD:10587 UMLS_CUI:C3164344 DOID:0060785 An adult onset demyelinating leukodystrophy characterized by autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS, presenting in the fourth or fifth decade of life, and that has_material_basis_in a heterozygous tandem genomic duplication on chromosome 5q23 that results in an extra copy of the lamin B1 gene (LMNB1), but also alters regulatory sequences that affect expression of other genes. SNOMEDCT_US_2025_09_01:448054001 MIM:169500 adult-onset autosomal dominant leukodystrophy autosomal-dominant or late-onset type Pelizaeus-Merzbacher disease autosomal dominant inheritance Adult onset