has material basis in autosomal recessive disease hypomyelinating leukodystrophy hypomyelinating leukodystrophy 12 disease_ontology DOID:0060796 MIM:616683 A hypomyelinating leukodystrophy characterized by autosomal recessive inheritance of severely delayed or even lack of psychomotor development that becomes apparent in the first months of life, acquired microcephaly and delayed myelination that has_material_basis_in homozygous mutation in the VPS11 gene on chromosome 11q23. HLD12 autosomal recessive inheritance