DO_rare_slim has material basis in autosomal dominant disease hypomyelinating leukodystrophy hypomyelinating leukodystrophy 6 MIM:612438 A hypomyelinating leukodystrophy characterized by infant or early childhood onset of delayed motor development and gait instability, followed by extrapyramidal movement disorders, progressive spastic tetraplegia, ataxia, hypomyelination, cerebellar atrophy, and atrophy or disappearance of the putamen that has_material_basis_in heterozygous mutation in the TUBB4A gene on chromosome 19p13. ORDO:139441 ICD10CM:E75.2 DOID:0060798 H-ABC HABC disease_ontology HLD6 hypomyelinating leukodystrophy with atrophy of the basal ganglia and cerebellum hypomyelination with atrophy of basal ganglia and cerebellum autosomal dominant inheritance