DO_rare_slim NCIthesaurus has material basis in syndromic X-linked intellectual disability syndromic X-linked intellectual disability 5 MIM:304340 DOID:0060800 ORDO:85335 MESH:C535773 SNOMEDCT_US_2025_09_01:719139003 ORDO:1568 UMLS_CUI:C0796254 NCI:C124839 disease_ontology A syndromic X-linked intellectual disability characterized by intellectual disability and variable features including choreoathetosis, hydrocephalus, Dandy-Walker malformation, seizures, and iron or calcium deposition in the brain that has_material_basis_in mutation in the AP1S2 gene on chromosome Xp22. Fried syndrome MRX59 MRXS21 Mental retardation, X-linked syndromic 5 Pettigrew syndrome X-linked intellectual disability-Dandy-Walker malformation-basal ganglia disease-seizures syndrome X-linked mental retardation 59 X-linked metal retardation with Dandy-Walker malformation, basal ganglia disease, and seizures syndromic X-linked mental retardation 21 syndromic X-linked mental retardation Fried type X-linked recessive disease X-linked recessive inheritance