has material basis in autosomal dominant disease dystonia 30 A dystonia characterized by the onset of symptoms in the first decades of life, with oromandibular, cervical, bulbar, or upper limb dystonia, and usually show slow progression to generalized dystonia. Some patients may lose ambulation and have neurocognitive impairment, including mild intellectual disability or psychiatric manifestations with has_material_basis_in heterozygous mutation in the VPS16 gene on chromosome 20p13. MIM:619291 DOID:0060937 DYT30 disease_ontology dystonia autosomal dominant inheritance