has material basis in disease has basis in autosomal dominant intellectual developmental disorder neurodevelopmental disorder with or without autism or seizures disease_ontology MIM:619239 DOID:0061147 An autosomal dominant intellectual developmental disorder characterized by global developmental delay apparent in infancy, impaired intellectual development, and speech delay. Some patients develop seizures, and may show regression after onset of seizures that has_material_basis_in heterozygous mutation in the CUL3 gene on chromosome 2q36. syndrome autosomal dominant inheritance symptom