mitochondrial axonal Charcot-Marie-Tooth disease A Charcot-Marie-Tooth disease characterized by onset of distal muscle weakness and atrophy mainly affecting the lower limbs and resulting in difficulty walking in the second decade of life, although both earlier and later onset can occur that has_material_basis_in mutation in the MTTV gene, which is encoded by the mitochondrial genome. disease_ontology MIM:500013 DOID:0061168 Charcot-Marie-Tooth disease