has material basis in autosomal recessive disease autosomal recessive brain small vessel disease 2B MIM:621414 DOID:0061233 A brain small vessel disease characterized by the onset of neurologic abnormalities in infancy or the first years of life, including global developmental delay, impaired intellectual development with poor or absent speech, seizures, and spastic quadriplegia that has_material_basis_in homozygous or compound heterozygous mutation in the COL4A2 gene on chromosome 13q34. disease_ontology brain small vessel disease autosomal recessive inheritance