has material basis in chromosomal deletion syndrome hereditary nonpolyposis colorectal cancer type 8 disease_ontology MIM:613244 DOID:0070270 A Lynch syndrome that has_material_basis_in heterozygous deletion of the 3' part of the EPCAM gene and intergenic regions adjacent to the MSH2 gene on chromosome 2p21. This results in transcriptional read-through and silencing of MSH2 in tissues expressing EPCAM. HNPCC8 Lynch syndrome deletion chromosome